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Perhaps I'm narrow-minded, but I tend to think modest and adamant are the only natures worth having. Your pokemon's going to have one base stat (attack or sp. attack) which is higher than the other. Therefore you can boost one of them, only use attacks of that kind and not negatively affect any of the other useful stats.
Well, Jolly and Timid are very much worth having as well, since you can then boost the Pokemon's Speed while decreasing the Attack-stat that it won't use anyway.
Choosing Jolly over Adamant or Timid over Modest can make a huge difference in a battle.
My only reservation with boosting a defense is that you only boost one. You still have a pretty good chance of coming up against an opponent with a beastly attack stat in the other defense. Although I know this is not a particularly good argument.Everyone seems to like the offensive natures, surprise surprise
Defence is just as (or even more) important.
Cool, collected...Calm