I can't think of much now, but I assume there is a few things, but some things I feel have altered since the start of the anime (not storyline, but some things):
"Gotta catch em all" has definatly gone, the original theory of catching one of every pokemon probably won't happen
Misty probably not returning, but even though she said she would when Ash/Brock and Misty departed in "Hoenn Alone" episode
TR voices, I preferred their older voices over newer ones, they sounded a slight bit lower in original series.
I can't think of anymore now, but what things do you think have changed since start?
"Gotta catch em all" has definatly gone, the original theory of catching one of every pokemon probably won't happen
Misty probably not returning, but even though she said she would when Ash/Brock and Misty departed in "Hoenn Alone" episode
TR voices, I preferred their older voices over newer ones, they sounded a slight bit lower in original series.
I can't think of anymore now, but what things do you think have changed since start?